Twickenham was originally founded in 1732 under a Grant from Englands King George II and was assembled by Walter Izzard in 1733. The main Plantation house was built in 1878 by Major John Screven and is a two-story home with 4 bedrooms and 3.5 baths. It was extensively remodeled over a 3-year period, and completed in 2018. While keeping the elegance of the 18th century, the house now boasts a myriad of modern features and improvements including a chefs kitchen with high-end appliances, expansive living rooms, plush bedrooms and renovated bathrooms. A formal dining room overlooks gardens designed by Robert Marvin and Douglas Duany, landscape architects who are credited with other works like the Augusta National Golf Club, Sea Pines Resort, and the Governors Mansion grounds.

In addition to the main house and gardens are two historic guesthouses that have also been completely restored and modernized, a managers house, horse barn, stables, and several additional storage barns. Away from the campus is a large pole barn, tractor shed, and grain bins.

Migrating species of all kinds call Twickenham home including teal, wood ducks, pintails, ringnecks, and many others. The current owner has re-engineered life back into the rice impoundments with major capital improvements in the functional hydraulics, reclaiming rice field ditches, widened and improved the dike system, and new trunks and risers placed with care to control water flow; all allowing the new owners to cultivate previously abandoned rice fields and expanding the footprint of hunting opportunities.

Much of the property is in old growth upland quail woods, and is a stunning example of decades of stewardship. Whitetails and turkeys have responded to proper quail management practices and are abundant on the property. Whitetails and turkeys remain largely an untapped hunting resource here. Trophy bucks and flocks of wild turkeys are regularly seen on evening outings.

Plantations across the river from Twickenham include Cherokee, Bluff, Plum Hill, Combahee, Myrtle Grove and others. On the Twickenham side of the river are Auldbrass, Old Combahee, Hobonny, Bonny Hall, Parkers Ferry, and others. To the south and east of Twickenham are Castle Hill, Cotton Hall, Tomotley, Bindon and more.

There are no conservation easements on Twickenham.